MTHFR Myths and Legends

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The Truth About MTHFR Gene Mutations

MTHFR mutations can impact detoxification and cellular energy generation due to metabolic backups, but their effect on overall mortality is minimal. Studies show conflicting results, with homocysteine emerging as a more reliable health marker with stronger mortality associations.

Myths vs. Reality of MTHFR Genotype

Contrary to popular belief, MTHFR genotype alone has little effect on mortality rates. However, it does significantly modify the total homocysteine mortality association. Clinical cases like Dana White's showcase higher homocysteine levels due to an MTHFR mutation, shedding light on its impact.

Contextualizing MTHFR Mutations

It's vital to consider MTHFR mutations in a broader clinical context. Clinical outcomes may not solely depend on supplements and genetic testing as publication bias can distort scientific findings and companies may misuse the scientific method for their products.

Value of Real Patient Experience

Real patient experiences hold valuable insights into the effects of MTHFR mutations. Highlighting the limitations of genetic testing, these experiences emphasize the importance of real-world data as a crucial source of knowledge.

High Sensitivity CRP: A Better Marker

High sensitivity CRP proves to be a more useful marker than homocysteine levels, especially in predicting heart diseases and indicating body inflammation. It can guide lifestyle changes for better health outcomes and predict cardiovascular mortality more accurately.

Impact of Lifestyle on Homocysteine Levels

Small variations in lifestyle, including diet, exercise, and routine, can significantly affect homocysteine levels. Lentils emerge as the king of the folate Hill, being the most dense folate food group, while green leafy vegetables may not be the primary source of folate intake.

Folate Intake and Mortality Relationship

Insufficient folate intake can lead to homocysteine-related issues and mortality risks. However, higher folate intake doesn't consistently reduce death risks, emphasizing that more does not necessarily equal better. It's crucial to avoid excess supplementation and focus on diet and food prep for reaching folate requirements.

Attention to Detail in Nutrition

Understanding specific foods, quantities of folate, and protein consumed is crucial for overall health. Lack of focus on these details can lead to mediocre healthcare results and confusion about creating wellness.


MTHFR gene mutations hold both truths and myths, and it's essential to distinguish between them. CRP emerges as a more reliable marker, and attention to detail in nutrition is key for overall health and well-being.

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