The B-6 Paradox: Debunking Common Misconceptions

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Understanding the Different Forms of Vitamin B6

Before we delve into the paradox, it's important to understand the different forms of vitamin B6. The active form, known as p5p or PLP, is crucial for various functions in the body. However, synthetic forms of B6, such as paradoxine, have been questioned for their effectiveness. The truth is that paradoxine exists in different conformers in nature, making it viable for clinical use. Both paradoxine HCL and paradoxine 5 phosphate can yield positive clinical outcomes.

Addressing Concerns about Synthetic B6 Supplements

Some individuals claim to have experienced harm from synthetic B6 supplements like paradoxine or paradoxine HCL. However, it's important to recognize that misleading posts can create a negative perception of clinicians who prescribe these supplements. Additionally, supplementation with high doses of pyridoxine (greater than 50 milligrams per day) for extended periods may be harmful. It's crucial to discourage such practices and prioritize evidence-based supplementation.

B6 Deficiency and Neuropathy

One common misconception is that B6 deficiency is the primary cause of neuropathy. While vitamin B6 deficiency can contribute to neuropathic symptoms, blaming it for all cases is unjustified. Neuropathy can have various causes, including other factors or nutritional deficiencies. However, it's worth noting that supplementing with pyridoxine can improve symptoms of B6 deficiency caused by certain conditions like isoniazid (ISID) treatment.

The Role of Mindset and Belief in B-6 Therapy

Belief and mindset play a crucial role in the effectiveness of therapies, including B-6 supplementation. Uncontrolled trials might be influenced by the placebo effect, suggesting that addressing nutritional imbalances alone may contribute to symptom improvement. However, one study found no significant change in nerve conduction studies after treatment with purdoxine, indicating the need for further research to validate its efficacy.

The Optimal Dosage and Form of B6 Supplements

Finding the right dosage and form of B6 supplements is vital for avoiding potential adverse effects. Very low doses of daily pyridoxine are sufficient for preventing peripheral neuropathy, while high doses can lead to neuropathic complaints. Testing for B6 levels and considering individual needs is essential for determining the appropriate dosage. Additionally, opting for supplements with the active form of B6, such as purdoxine HCL, ensures optimal results.

Realizing the Importance of Personalized Support and Guidance

In the world of health and wellness, investing in personalized support and guidance can make all the difference. Coaching programs and access to valuable resources can help you navigate the complexities of nutritional supplementation and lifestyle modifications. By subscribing to our newsletter at, you can gain access to free webinars and exclusive content that will empower you on your wellness journey.


In conclusion, the B-6 paradox is a complex topic that requires careful consideration. By debunking misconceptions and providing accurate information, we hope to empower you to make informed decisions about vitamin B6 supplementation. Remember, personalized support, proper dosage, and a balanced approach to nutrition are key factors in optimizing your health. Subscribe to our newsletter for ongoing guidance and take control of your wellness journey today. Join our email list for weekly webinars and stay informed about upcoming health topics.


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